Prolonged daily exposure to IV cocaine results in tolerance to its stimulant effects
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چکیده
منابع مشابه
Neurobehavioral Effects of Prolonged Exposure to Solid Air Freshener in Mice
Background: Air fresheners are products with fragrances used to mask unpleasant odor in the environment. However, air fresheners contain diverse chemical substances that pose health challenges to the users; hence are of public health significance. Although previous studies have shown that air fresheners affect the lungs, liver and reproductive organs, the neurobehavioral effects of these agent...
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Objective(s):Reduction of pharmacological effectiveness or tolerance appears following repeated administration of many analgesic drugs. We investigated tolerance to anti-nociceptive effects of orexin-A, an endogenous potent analgesic peptide using the hot-plate test.Materials and Methods:Orexin-A was microinjected ICV (intracerebroventricular) with an interval of 12 hr for 7 continuous days and...
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T HE JET age of aircraft design and the rocket age which promises to follow have brought entirely new problems to aviation medicine. These aircraft, flying at supersonic speeds, require longer time periods to complete even simple maneuvers. The accompanying prolonged accelerations will create rapidly increasing demands on cardiovascular function and the nervous system. The problem of dealing wi...
متن کامل[Prenatal exposure to cocaine: review of the neurobehavioral effects]
OBJECTIVE: To study prenatal cocaine exposure, emphasizing its behavioral effects. METHODS: Literature review of the last 15 years, through Medline and direct search. RESULTS AND CONCLUSIONS: According to the literature, the incidence of prenatal cocaine exposure is up to 15.5%, and its effects on the newborn are particularly on the development of the nervous system. Pediatricians and sub-speci...
متن کاملStimulant preexposure sensitizes rats and humans to the rewarding effects of cocaine.
A great deal of research has focused on initiation into drug use and factors that increase the risk of initiation or protect against it. Initiation into the use of some drugs (such as alcohol) is extremely common, whereas initiation into use of other drugs (such as cocaine) is less frequent (Kandel 1975). Regardless of initiation rate, most individuals who try a particular drug do not continue ...
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ژورنال
عنوان ژورنال: Pharmacology Biochemistry and Behavior
سال: 2005
ISSN: 0091-3057
DOI: 10.1016/j.pbb.2005.09.013